Structure of PDB 5ckm Chain A Binding Site BS03

Receptor Information
>5ckm Chain A (length=277) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KWPEPVFGRLVSPGFPEKYGNHQDRSWTLTAPPGFRLRLYFTHFNLELSY
RCEYDFVKLTSGTKVLATLCGQESTDTERAPGNDTFYSLGPSLKVTFHSD
YSNEKPFTGFEAFYAAEDVDECRTSLGDSVPCDHYCHNYLGGYYCSCRVG
YILHQNKHTCSALCSGQVFTGRSGFLSSPEYPQPYPKLSSCAYNIRLEEG
FSITLDFVESFDVEMHPEAQCPYDSLKIQTDKREYGPFCGKTLPPRIETD
SNKVTITFTTDESGNHTGWKIHYTSTA
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5ckm Chain A Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5ckm Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation.
Resolution2.73 Å
Binding residue
(original residue number in PDB)		E215 D225 D262 S264
Binding residue
(residue number reindexed from 1)		E214 D224 D261 S263
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.104: mannan-binding lectin-associated serine protease-2.
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:5ckm, PDBe:5ckm, PDBj:5ckm
PDBsum5ckm
PubMed28111019
UniProtQ9JJS8|MASP2_RAT Mannan-binding lectin serine protease 2 (Gene Name=Masp2)

[Back to BioLiP]