Structure of PDB 5cg8 Chain A Binding Site BS03

Receptor Information
>5cg8 Chain A (length=266) Species: 5762 (Naegleria gruberi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MINKKSLLQNLLSKCKTTFQQSFTNANITLKDEKWLKNVRTAYFVCDHDG
SVELAYLPNVLPKELVEEFTEKFESIQTGRKKDTGYSGILDNSMPFNYVT
ADLSQELGQYLSEIVNPQINYYISKLLTCVSSRTINYLVSLNDSYYALNN
CLYPSTAFNSLKPSNDGHRIRKPHKDNLDITPSSLFYFGNFQNTEGYLEL
TDKNCKVFVQPGDVLFFKGNEYKHVVANITSGWRIGLVYFAHKGSKTKPY
YEDTQKNSLKIHKETK
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain5cg8 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5cg8 Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA.
Resolution2.702 Å
Binding residue
(original residue number in PDB)		N214 R224 H229 D231 L240 Y242 L253 H279 V281 R289
Binding residue
(residue number reindexed from 1)		N159 R169 H174 D176 L185 Y187 L198 H224 V226 R234
Annotation score5
Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
External links
PDB RCSB:5cg8, PDBe:5cg8, PDBj:5cg8
PDBsum5cg8
PubMed26323320
UniProtD2W6T1|TET1_NAEGR Tet-like dioxygenase 1 (Gene Name=TET1)

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