Structure of PDB 5bte Chain A Binding Site BS03

Receptor Information

>5bte Chain A (length=365) Species: 284811 (Eremothecium gossypii ATCC 10895)

SELLLQRRLATTALKQPKELGYYSTNVGGELKVMDESNLSYYYLPDADIE
KHIDLSAGARKFQDEQAEAEDDTGSLHGLLQTLMEYERRKSKKVNADIIA
FRGQVKRLIHCAFGGHATDVDMYVMSFDGQLFIRAARKKLEFPTSPRESW
AYLAYYSGYKFERMALLDRPVAETPREVLESRGKQVVRNGPQYKTVVRTG
VGEHKLVLGAEVDGIFDFREPTGDNLKHYVELKVAKKVQTLKDATNFEQK
LFSVWLQCFLVGINRVIIGFRDEKFVLKSVEEFSTSEIPLLLKSTRNACV
DAIKWYGALTKWLCELPRGPEDDFKLYRLSCSRGALHLRQLHDEDLANGD
DIIPGWFREWRRSLS

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 5bte Chain C Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5bte Structural and biochemical studies of the distinct activity profiles of Rai1 enzymes.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): E215 D217
• Binding residue (residue number reindexed from 1): E211 D213
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.13.-
  3.6.1.-

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003723 RNA binding
• GO:0004527 exonuclease activity
• GO:0034353 mRNA 5'-diphosphatase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000956 nuclear-transcribed mRNA catabolic process
• GO:0006397 mRNA processing
• GO:0110155 NAD-cap decapping

Cellular Component

• GO:0005634 nucleus
• GO:0005829 cytosol

External links

• PDB: RCSB:5bte, PDBe:5bte, PDBj:5bte
• PDBsum: 5bte
• PubMed: 26101253
• UniProt: Q753P9|DXO_EREGS Decapping nuclease RAI1 (Gene Name=RAI1)