Structure of PDB 5b2p Chain A Binding Site BS03

Receptor Information
>5b2p Chain A (length=1455) Species: 401614 (Francisella tularensis subsp. novicida U112) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNFKILPIAIDLGVKNTGVFSAFYQKGTSLERLDNKNGKVYELSKDSYTL
LMNNRTARRHQRRGIDRKQLVKRLFKLIWTEQLNLEWDKDTQQAISFLFN
RRGFSFITDGYSVKAILMDIFDDYNGEDDSYLKLATEQESKISEIYNKLM
QKILEFKLMKLCTDIKDDTLKEITSYEFELLADYLANYSESLKTQKFYNI
QEFLKRHATINDRILDTLLTDDLDIWNFNFELHHFVFAVNKIKSEMASGG
RHRSQYFQEITNVLDENNHQEGYLKNFCENLHNKKYSNLSVKNLVNLIGN
LSNLELKPLRKYFNDKIHAKADHWDEQKFTETYCHWILGEWRVGVKDQDK
KDGAKYSYKDLCNELKQKVTKAGLVDFLLELDPCRTIPPYLDNNNRKPPK
CQSLILNPKFLDNQYPNWQQYLQELKKLQSIQNYLDSFETDLKVLKSSKD
QPYFVEYKSSNQQIASGQRDYKDLDARILQFIFDRVKASDELLLNEIYFQ
AKKLKQESSKKLDEVIANSQLSQILKSQHTNGIFEQGTFLHLVCKYYKQR
QRARDSRLYIMPEYRYDKKLHKYNNTGRFDDDNQLLTYCNHKPRQKRYQL
LNDLAGVLQVSPNFLKDKIGSDDDLFISKWLVEHIRGFKKACEDSLKIQK
DNRGLLNHKINIARNTKGKCEKEIFNLICKIEGYKHGLAYELGVLLFGEP
NEASKPEFDRKIKKFNSIYSFAQIQQIAFAERKGNANTCAVCSADNAHRM
QQIKIILSAKAQRLPAIPTRIVDGAVKKMATILAKNIVDDNWQNIKQVLS
AKHQLHIPIITESNAFEFEPALADVKGKSLKDRRKKALERISPENIFKDK
NNRIKEFAEELDHIIPRTLNDEANLICVTGNRIFCLRDNYRSFINLTPQE
QKAFRHALFLADENPIKQAVIRAINNRNRTFVNGTQRYFAEVLANNIYLR
AKKENLNTDKISFDYFGIPTIGNGRGIAEIRQLYEKVDSDIQAYAKGDKP
QASYSHLIDAMLAFCIAADEHRNDGSIGLEIDKNYSLYPDIFSQIKITDN
EFSDKKLVRKKAIEGFNTHRQMTRDGIYAENYLPILIHKELNEVRKGYTW
KNSEEIKIFKGKKYDIQQLNNLVYCLKFVDKPISIDIQISTLEELRNILT
TNNIAATAEYYYINLKTQKLHEYYIENYNTALGYKKYSKEMEFLRSLAYR
SERVKIKSIDDVKQVLDKDSNFIIGKITLPFKKEWQRLYREWQNTTIKDD
YEFLKSFFNVKSITKLHKKVRKDFSLPISTNEGKFLVKRKTWDNNFIYQI
LNDSDSRADGTKPFIPAFDISKNEIVEAIIDSFTSKNIFWLPKNIELQKV
DNKNIFAIDTSKWFEVETPSDLRDIGIATIQYKIDNNSRPKVRVKLDYVI
DDDSKINYFMNHSLLKSRYPDKVLEILKQSTIIEFESSGFNKTIKEMLGM
KLAGI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5b2p Structure and Engineering of Francisella novicida Cas9
Resolution1.7 Å
Binding residue
(original residue number in PDB)		N1448 K1451 D1470 S1473 R1474 P1509 N1554 S1555 R1556 K1558 R1585 Y1586 E1603
Binding residue
(residue number reindexed from 1)		N1281 K1284 D1303 S1306 R1307 P1342 N1387 S1388 R1389 K1391 R1418 Y1419 E1436
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:5b2p, PDBe:5b2p, PDBj:5b2p
PDBsum5b2p
PubMed26875867
UniProtA0Q5Y3|CAS9_FRATN CRISPR-associated endonuclease Cas9 (Gene Name=cas9)

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