Structure of PDB 5ahm Chain A Binding Site BS03

Receptor Information

>5ahm Chain A (length=354) Species: 208964 (Pseudomonas aeruginosa PAO1)

MLRISQEALTFDDVLLIPGYSEVLPKDVSLKTRLTRGIELNIPLVSAAMD
TVTEARLAIAMAQEGGIGIIHKNMGIEQQAAEVRKVKKHETAKAKTYPLA
SKDEQGRLRVGAAVGTGADTGERVAALVAAGVDVVVVDTAHGHSKGVIER
VRWVKQTFPDVQVIGGNIATAEAAKALAEAGADAVKVGIGPGSICTTRIV
AGVGVPQISAIANVAAALEGTGVPLIADGGIRFSGDLAKAMVAGAYCVMM
GSMFAGTEEAPGEIELFQGRSYKSYRGMGSLVPEGIEGRVPYKGALSAIV
HQLMGGLRAAMGYTGSADIQQMRTQPQFVRITGAGMAESHVHDVQITKEA
PNYR

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 5ahm Chain A Residue 1489

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5ahm Crystallographic Studies of Two Variants of Pseudomonas Aeruginosa Impdh with Impaired Allosteric Regulation
• Resolution: 1.74 Å
• Binding residue (original residue number in PDB): D212 E213 R218
• Binding residue (residue number reindexed from 1): D103 E104 R109
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.1.1.205: IMP dehydrogenase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0003938 IMP dehydrogenase activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0006164 purine nucleotide biosynthetic process

External links

• PDB: RCSB:5ahm, PDBe:5ahm, PDBj:5ahm
• PDBsum: 5ahm
• PubMed: 26327379
• UniProt: Q9HXM5