Structure of PDB 4z31 Chain A Binding Site BS03
Receptor Information
>4z31 Chain A (length=293) Species:
9606
(Homo sapiens) [
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NKHYEVAKKCVEDLALYLKPALSRPMQRKLVTLVNCQLVEEEGRVRAMRA
ARSLGERTVTELILQHQNPQQLSANLWAAVRARGCQFLGPAMQEEALKLV
LLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKV
TKRDEDSSLMQLKEEFRSYEALRREHDAQIVHIAMEAGLRISPEQWSSLL
YGDLAHKSHMQSIIDKLQSPESFAKSVQELTIVLQRTGDPANLNRLRPHL
ELLANIDPNPDAVSPTWEQLENAMVAVKTVVHGLVDFIQNYSR
Ligand information
>4z31 Chain F (length=15) [
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auguucugugaacac
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Receptor-Ligand Complex Structure
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PDB
4z31
New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
R185 R187 R216 K217 S235 T237 Q244 Y247 R248 E259 D260 S261 S262
Binding residue
(residue number reindexed from 1)
R81 R83 R112 K113 S131 T133 Q140 Y143 R144 E155 D156 S157 S158
Binding affinity
PDBbind-CN
: Kd=356nM
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
External links
PDB
RCSB:4z31
,
PDBe:4z31
,
PDBj:4z31
PDBsum
4z31
PubMed
26489670
UniProt
Q9HBD1
|RC3H2_HUMAN Roquin-2 (Gene Name=RC3H2)
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