Structure of PDB 4xwt Chain A Binding Site BS03

Receptor Information

>4xwt Chain A (length=543) Species: 1299 (Deinococcus radiodurans)

APTLEVIPLGGMGEIGKNITVFRYGDEIVVVDGGLAFPKAHQMGIDLIVP
RIDYLLEHQDKIKGWILTHGHEDHIGGLPYIFARLPRVPVYGLPLTLALV
REKLSEFGLQDVDLREVTYGDEVRFGQSFVAEFFCMTHSIPDNAGYILKT
PVGDVLHTGDFKIDPDVGTGAGIVSDLERVEQAGKDGVLLLISDSTNAER
PGHTPSEAEIARNLEEIIKGCRGRVFLTTFASQVYRIQNILDLAHRQGRR
VVMEGRSMIKYAQAAQATGHMNPPEPFLTSEEVGELQDQQVLFVCTGSQG
QPMAVLGRLAFGTHAKIALRRGDTVILSSNPIPGNEDAVNLIVNRLYEIG
VDVVYPPTYRVHASGHASQEELATILNLTRPKFFLPWHGEPRHQINHAKL
AQTLPRPPKRTLIAKNGDIVNLGPDEFRVSGTVAAGAVYVDGLGVGDVND
DVLLDRVNLSQEGLLILTAVLHPTPHVEVVARGFARPNRDLELQIRRVAL
EAVEQGLREKKRLEDVRDDMYGAVRRFTRKATGRNPVLIPMIV

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 4xwt Chain A Residue 603

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4xwt Structural insights into catalysis and dimerization enhanced exonuclease activity of RNase J
• Resolution: 2.003 Å
• Binding residue (original residue number in PDB): G59 D456
• Binding residue (residue number reindexed from 1): G44 D441
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0004521 RNA endonuclease activity
• GO:0004527 exonuclease activity
• GO:0004534 5'-3' RNA exonuclease activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006364 rRNA processing
• GO:0006396 RNA processing

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4xwt, PDBe:4xwt, PDBj:4xwt
• PDBsum: 4xwt
• PubMed: 25940620
• UniProt: H9CZL7