Structure of PDB 4xlw Chain A Binding Site BS03

Receptor Information
>4xlw Chain A (length=113) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DECALGANPCEHAGKCLNTLGSFECQCLQGYTGPRCEIDVNECISNPCQN
DATCLDQIGEFQCICMPGYEGVYCEINTDECASSPCLHNGRCVDKINEFL
CQCPKGFSGHLCQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4xlw Chain A Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4xlw Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
Resolution3.39 Å
Binding residue
(original residue number in PDB)		N490 T491 E493 D507 K508
Binding residue
(residue number reindexed from 1)		N77 T78 E80 D94 K95
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:4xlw, PDBe:4xlw, PDBj:4xlw
PDBsum4xlw
PubMed25700513
UniProtQ07008|NOTC1_RAT Neurogenic locus notch homolog protein 1 (Gene Name=Notch1)

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