Structure of PDB 4xi7 Chain A Binding Site BS03

Receptor Information

>4xi7 Chain A (length=362) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGT
AANYRCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNY
DLCTVCYHGDKHHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAGAR
VVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYR
VGFEGMSDLKCVQDAKGGSFYRDHCPVLGVNIDLDLEIVQSLQHGHGGWT
DGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKASQFQVGDL
VQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGT
SWTYNPAAVSKV

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

4xi7 Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4xi7 A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Resolution	2.051 Å
Binding residue (original residue number in PDB)	C100 C103 H118 H122
Binding residue (residue number reindexed from 1)	C94 C97 H112 H116
Annotation score	4

Enzymatic activity

Enzyme Commision number

2.3.2.27: RING-type E3 ubiquitin transferase.

Gene Ontology

	Molecular Function
GO:0004842	ubiquitin-protein transferase activity
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

	Biological Process
GO:0016567	protein ubiquitination

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Molecular Function

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Biological Process

External links

PDB	RCSB:4xi7, PDBe:4xi7, PDBj:4xi7
PDBsum	4xi7
PubMed	25747658
UniProt	Q86YT6\|MIB1_HUMAN E3 ubiquitin-protein ligase MIB1 (Gene Name=MIB1)

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