Structure of PDB 4x9p Chain A Binding Site BS03

Receptor Information
>4x9p Chain A (length=314) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDI
AFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMTDE
DSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALA
KGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHL
QKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLY
DSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKG
DYQKALLYLCGGDD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4x9p Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4x9p The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects.
Resolution2.01 Å
Binding residue
(original residue number in PDB)		G50 V51 E53
Binding residue
(residue number reindexed from 1)		G29 V30 E32
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0004859 phospholipase inhibitor activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0031214 biomineral tissue development
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0031982 vesicle
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0065010 extracellular membrane-bounded organelle

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4x9p, PDBe:4x9p, PDBj:4x9p
PDBsum4x9p
PubMed25772737
UniProtP04272|ANXA2_BOVIN Annexin A2 (Gene Name=ANXA2)

[Back to BioLiP]