Structure of PDB 4wzv Chain A Binding Site BS03

Receptor Information

>4wzv Chain A (length=158) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYS
RDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWS
LGKGVGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDV
NGIRHLYG

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

4wzv Chain A Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4wzv N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.
Resolution	1.65 Å
Binding residue (original residue number in PDB)	H175 D177 H190 H203
Binding residue (residue number reindexed from 1)	H64 D66 H79 H92
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	H226 E227 H230 H236
Catalytic site (residue number reindexed from 1)	H115 E116 H119 H125
Enzyme Commision number	3.4.24.35: gelatinase B.

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0031012	extracellular matrix

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Cellular Component

External links

PDB	RCSB:4wzv, PDBe:4wzv, PDBj:4wzv
PDBsum	4wzv
PubMed	26263024
UniProt	P14780\|MMP9_HUMAN Matrix metalloproteinase-9 (Gene Name=MMP9)

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