Structure of PDB 4wxu Chain A Binding Site BS03

Receptor Information
>4wxu Chain A (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGT
DVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRT
VIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYS
TDDAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYT
SADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLN
MVTYDIKLS
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain4wxu Chain A Residue 606 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4wxu Structural basis for misfolding in myocilin-associated glaucoma.
Resolution2.092 Å
Binding residue
(original residue number in PDB)		M271 R272 V328 V329 Y479 N480 F487
Binding residue
(residue number reindexed from 1)		M28 R29 V85 V86 Y236 N237 F244
Annotation score1
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:4wxu, PDBe:4wxu, PDBj:4wxu
PDBsum4wxu
PubMed25524706
UniProtQ99972|MYOC_HUMAN Myocilin (Gene Name=MYOC)

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