Structure of PDB 4wuz Chain A Binding Site BS03

Receptor Information
>4wuz Chain A (length=226) Species: 10710 (Lambdavirus lambda) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTPDIILQRTGIDVRAVEQGDDAWHKLRLGVITASEVHNVIAKPRSGKKW
PDMKMSYFHTLLAEVCTGVAPEVNAKALAWGKQYENDARTLFEFTSGVNV
TESPIIYRDESMRTACSPDGLCSDGNGLELKCPFTSRDFMKFRLGGFEAI
KSAYMAQVQYSMWVTRKNAWYFANYDPRMKREGLHYVVIERDEKYMASFD
EIVPEFIEKMDEALAEIGFVFGEQWR
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain4wuz Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4wuz Crystal Structure of lambda Exonuclease in Complex with DNA and Ca(2+).
Resolution2.38 Å
Binding residue
(original residue number in PDB)		R28 T33 A34 S35 C116 S117
Binding residue
(residue number reindexed from 1)		R28 T33 A34 S35 C116 S117
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) E93 E102 D109 E129 L130 K131
Catalytic site (residue number reindexed from 1) E93 E102 D109 E129 L130 K131
Enzyme Commision number 3.1.11.3: exodeoxyribonuclease (lambda-induced).
Gene Ontology
Molecular Function
GO:0004527 exonuclease activity
GO:0046872 metal ion binding
GO:0051908 double-stranded DNA 5'-3' DNA exonuclease activity
Biological Process
GO:0006259 DNA metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4wuz, PDBe:4wuz, PDBj:4wuz
PDBsum4wuz
PubMed25370446
UniProtP03697|EXO_LAMBD Exonuclease (Gene Name=exo)

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