Structure of PDB 4wrn Chain A Binding Site BS03

Receptor Information
>4wrn Chain A (length=693) Species: 9606,83334 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHHHHHHKTEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKL
EEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFT
WDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKG
KSALMFNLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLT
FLVDLIKNKHMNADTDYSIAEHAFNHGETAMTINGPWAWSNIDTSAVNYG
VTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAV
NKDKPLGAVALKSYEEELVKDPRVAATMENAQKGEIMPNIPQMSAFWYAV
RTAVINAASGRQTVDAALAAAQTNAAAGTCEECSIDEDCKSNNGRWHCQC
KQDFNITDISLLEHRLECGANDMKVSLGKCQLKSLGFDKVFMYLSDSRCS
GFNDRDNRDWVSVVTPARDGPCGTVLTRNETHATYSNTLYLADEIIIRDL
NIKINFACSYPLDMKVSLKTALQPMVSALNIRVGGTGMFTVRMALFQTPS
YTQPYQGSSVTLSTEAFLYVGTMLDGGDLSRFALLMTNCYATPSSQATDP
LKYFIIQDRCPHTRDSTIQVVENGESSQGRFSVQMFRFAGNYDLVYLHCE
VYLCDTMNEKCKPTCSGTAFASGSVIDQSRVLNLGPITRKGVQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4wrn Chain A Residue 804 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4wrn A structured interdomain linker directs self-polymerization of human uromodulin.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H20 H24 E302
Binding residue
(residue number reindexed from 1)		H3 H7 E285
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015144 carbohydrate transmembrane transporter activity
GO:1901982 maltose binding
Biological Process
GO:0008643 carbohydrate transport
GO:0015768 maltose transport
GO:0034219 carbohydrate transmembrane transport
GO:0042956 maltodextrin transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wrn, PDBe:4wrn, PDBj:4wrn
PDBsum4wrn
PubMed26811476
UniProtP07911|UROM_HUMAN Uromodulin (Gene Name=UMOD);
P0AEY0|MALE_ECO57 Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE)

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