Structure of PDB 4rea Chain A Binding Site BS03

Receptor Information
>4rea Chain A (length=590) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EFPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYVR
LFQRKLSWIKMTKLEYEEIALDLTPVIEELTNAGFLQTESELQELSEVLE
LLSAPELKSLAKTFHLVNPNGQKQQLVDAFLKLAKQGIGAVILKRAKALA
GQSVRICKGPRAVFSRILLLFSLTDSMELLVNLGRMEFPSYTINRKTHIF
QDRDDLIRYAAATHMLSDISSAMANGNWEEAKELAQCAKRDWNRLKNHPS
LRCHEDLPLFLRCFTVGWIYTRILSRFVEILQRLHMYEEAVRELESLLSQ
RIYCPDSRGRWWDRLALNLHQHLKRLEPTIKCITEGLADPEVRTGHRLSL
YQRAVRLRESPSCKKFKHLFQQLPEMAVQDVKHVTITGRLCLCSVEELAL
AHYRRSGFDQGIHGEGSTFSTLYGLLLWDIIFMDGIPDVFRNACQAFPLD
LCTDSFFTSRRPALEARLQLIHDAPEESLRAWVAATWHEQEGRVASLVSW
DRFTSLQQAQDLVSCLGGPVLSGVCRHLAADFRHCRGGLPALVVWNSQSR
HFKLVEVKGPNDRLSHKQMIWLAELQKLGAEVEVCHVVAV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4rea Structural insights into 5' flap DNA unwinding and incision by the human FAN1 dimer.
Resolution3.81 Å
Binding residue
(original residue number in PDB)		E390 K406 Q409
Binding residue
(residue number reindexed from 1)		E20 K36 Q39
Enzymatic activity
Enzyme Commision number 3.1.21.-
3.1.4.1: phosphodiesterase I.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0036297 interstrand cross-link repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4rea, PDBe:4rea, PDBj:4rea
PDBsum4rea
PubMed25500724
UniProtQ9Y2M0|FAN1_HUMAN Fanconi-associated nuclease 1 (Gene Name=FAN1)

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