Structure of PDB 4r8a Chain A Binding Site BS03

Receptor Information
>4r8a Chain A (length=538) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPEPFYYLHNFRAVLAWIGERYADLLDDQERAFIAAFAELPEASQALLVR
MVMRKGTLFREGKLAYAEIGDTRAAVQPLLALGWVDAQPTLELAQLFGLL
KKDELSQLFRDHLGRANLRKDALLERLQPLFPEARRLAEWQADFAEPVYE
LRCMALCDRLRLMYFGNLWQDWSEFVLADLGIYRYESVEFSADSRGFRLR
ADVDAYLHLFDCRQRFDLGEPLEELLAGLPGEPYANPWLEGRRVKLLFQF
AQHCEKQRDFDLAQRLYRQSSHPGARLRAIRSLERGERFAEAHALAREAS
CAPESDAERQGLARLLPRLQGKLGLPRQARAAAPEIDRLDLCLAFPSEPC
SVEWAVREHLEEPGCAVHYVENGLINSLFGLLCWEAIFAAIPGAFFHPFH
SAPADLHSADFRQRRAALFEACLGRLEDGSYRDAIRCRYRDKFGLQSPFV
YWELLGEELLEQALDCLPAAHLRAWFERLLEDIPGNRAGLPDLIQFWPAQ
RRYRMVEVKGPGDRLQDNQLRWLQFCREREMPVAVCYV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4r8a Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1
Resolution3.2 Å
Binding residue
(original residue number in PDB)		K78 K116 K117 R134 K135 L192 I197 Y198 K271 R293 R296 R300 R329 R333 R529
Binding residue
(residue number reindexed from 1)		K63 K101 K102 R119 K120 L177 I182 Y183 K256 R278 R281 R285 R314 R318 R514
Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0004528 phosphodiesterase I activity
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070336 flap-structured DNA binding
Biological Process
GO:0006281 DNA repair
GO:0036297 interstrand cross-link repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4r8a, PDBe:4r8a, PDBj:4r8a
PDBsum4r8a
PubMed25319828
UniProtQ9I2N0|FAN1_PSEAE Fanconi-associated nuclease 1 homolog (Gene Name=fan1)

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