Structure of PDB 4r89 Chain A Binding Site BS03

Receptor Information
>4r89 Chain A (length=537) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEPFYYLHNFRAVLAWIGERYADLLDDQERAFIAAFAELPEASQALLVRM
VMRKGTLFREGKLAYAEIGDTRAAVQPLLALGWVDAQPTLELAQLFGLLK
KDELSQLFRDHLGRANLRKDALLERLQPLFPEARRLAEWQADFAEPVYEL
RCMALCDRLRLMYFGNLWQDWSEFVLADLGIYRYESVEFSADSRGFRLRA
DVDAYLHLFDCRQRFDLGEPLEELLAGLPGEPYANPWLEGRRVKLLFQFA
QHCEKQRDFDLAQRLYRQSSHPGARLRAIRSLERGERFAEAHALAREASC
APESDAERQGLARLLPRLQGKLGLPRQARAAAPEIDRLDLCLAFPSEPCS
VEWAVREHLEEPGCAVHYVENGLINSLFGLLCWEAIFAAIPGAFFHPFHS
APADLHSADFRQRRAALFEACLGRLEDGSYRDAIRCRYRDKFGLQSPFVY
WELLGEELLEQALDCLPAAHLRAWFERLLEDIPGNRAGLPDLIQFWPAQR
RYRMVEVKGPGDRLQDNQLRWLQFCREREMPVAVCYV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4r89 Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1
Resolution4.002 Å
Binding residue
(original residue number in PDB)		K116 K117 R134 K135 L192 I197 R293 R296 R329 R333 R345 R529
Binding residue
(residue number reindexed from 1)		K100 K101 R118 K119 L176 I181 R277 R280 R313 R317 R329 R513
Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0004528 phosphodiesterase I activity
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070336 flap-structured DNA binding
Biological Process
GO:0006281 DNA repair
GO:0036297 interstrand cross-link repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4r89, PDBe:4r89, PDBj:4r89
PDBsum4r89
PubMed25319828
UniProtQ9I2N0|FAN1_PSEAE Fanconi-associated nuclease 1 homolog (Gene Name=fan1)

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