Structure of PDB 4qzd Chain A Binding Site BS03

Receptor Information
>4qzd Chain A (length=348) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKKISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRASS
VLKSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDERY
KSFKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLYY
EDLVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVDF
LITSPEATEDEEQQLLHKVTDFWKQQGLLLYCDILESTFEKFKDHFQKCA
LILKLDHGRVHSGKGWKAIRVDLVMCPYDRRAFALLGWTGSRQFERDLRR
YATHERKMMLDNHALYDRTKRVFLEAESEEEIFAHLGLDYIEPWERNA
Ligand information
Receptor-Ligand Complex Structure
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PDB4qzd Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		G257 G259 K261 T262 D434
Binding residue
(residue number reindexed from 1)		G111 G113 K115 T116 D272
Enzymatic activity
Catalytic site (original residue number in PDB) D343 D345 D434
Catalytic site (residue number reindexed from 1) D197 D199 D272
Enzyme Commision number 2.7.7.31: DNA nucleotidylexotransferase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4qzd, PDBe:4qzd, PDBj:4qzd
PDBsum4qzd
PubMed25762590
UniProtP09838|TDT_MOUSE DNA nucleotidylexotransferase (Gene Name=Dntt)

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