Structure of PDB 4q10 Chain A Binding Site BS03

Receptor Information

>4q10 Chain A (length=300) Species: 559292 (Saccharomyces cerevisiae S288C)

GVHSFWDIAGPTARPVRLESLEDKRMAVDASIWIYQFLKAVRVKNSHITG
FFRRICKLLYFGIRPVFVFDGGVPVLKRETIRQDEVTMDMIKEVQELLSR
FGIPYITAPMEAEAQCAELLQLNLVDGIITDDSDVFLFGGTKIYKNMFHV
EFYDAESILKLLGLDRKNMIELAQLLGSDYTNGLKGMGPVSSIEVIAEFG
NLKNFKDWYNNGQFDKRKQETENKFEKDLRKKLVNNEIILDDDFPSVMVY
DAYMRPEVDHDTTPFVWGVPDLDMLRSFMKTQLGWPHEKSDEILIPLIRD

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 4q10 Chain A Residue 1001

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4q10 Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): E794 D813 D815
• Binding residue (residue number reindexed from 1): E113 D132 D134
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003697 single-stranded DNA binding
• GO:0003824 catalytic activity
• GO:0004518 nuclease activity
• GO:0004519 endonuclease activity
• GO:0016788 hydrolase activity, acting on ester bonds

Biological Process

• GO:0006289 nucleotide-excision repair

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:4q10, PDBe:4q10, PDBj:4q10
• PDBsum: 4q10
• PubMed: 25120270
• UniProt: P07276|RAD2_YEAST DNA repair protein RAD2 (Gene Name=RAD2)