Structure of PDB 4poe Chain A Binding Site BS03

Receptor Information

>4poe Chain A (length=295) Species: 5059 (Aspergillus flavus)

SAVKAARYGKDNVRVYKVHKDEKTGVQTVYEMTVCVLLEGEIETSYTKAD
NSVIVATDSIKNTIYITAKQNPVTPPELFGSILGTHFIEKYNHIHAAHVN
IVCHRWTRMDIDGKPHPHSFIRDSEEKRNVQVDVVEGKGIDIKSSLSGLT
VLKSTNSQFWGFLRDEYTTLKETWDRILSTDVDATWQWKNFSGLQEVRSH
VPKFDATWATAREVTLKTFAEDNSASVQATMYKMAEQILARQQLIETVEY
SLPNKHYFEIDLSWHKGLQNTGKNAEVFAPQSDPNGLIKCTVGRS

Ligand information

• Ligand ID: NA
• InChI: InChI=1S/Na/q+1
• InChIKey: FKNQFGJONOIPTF-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Na+]
• Formula: Na
• Name: SODIUM ION
• DrugBank: DB14516
• PDB chain: 4poe Chain A Residue 403

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4poe Azide inhibition of urate oxidase.
• Resolution: 1.07 Å
• Binding residue (original residue number in PDB): I88 Y91 N92 I94 E136
• Binding residue (residue number reindexed from 1): I88 Y91 N92 I94 E136
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): K10 T57 R176 Q228 H256
• Catalytic site (residue number reindexed from 1): K10 T57 R176 Q228 H256
• Enzyme Commision number: 1.7.3.3: factor independent urate hydroxylase.

Gene Ontology

Molecular Function

• GO:0004846 urate oxidase activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0006144 purine nucleobase metabolic process
• GO:0006145 purine nucleobase catabolic process
• GO:0019628 urate catabolic process

Cellular Component

• GO:0005777 peroxisome

External links

• PDB: RCSB:4poe, PDBe:4poe, PDBj:4poe
• PDBsum: 4poe
• PubMed: 25005084
• UniProt: Q00511|URIC_ASPFL Uricase (Gene Name=uaZ)