Structure of PDB 4pk4 Chain A Binding Site BS03

Receptor Information
>4pk4 Chain A (length=758) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPVWAPHPTDGFQVGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEED
SKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIP
KIYSSETIKSYQGKSLGTMPPHVFAIADKAFRDMKVLKLSQSIIVSGESG
AGKTENTKFVLRYLTESYGTGQDIDDRIVEANPLLEAFGNAKTVRNNNSS
RFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAG
ASEDIRERLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAG
SLKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEE
AGSTSGGCNLKNKSTQALEYCAELLGLDQDDLRVSLTTRVMIKVPLKVEQ
ANNARDALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEH
NSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCI
DLIEARLVGILDILDEENRLPQPSDQHFTSAVHQKHKDHFRLSIPRKSKL
AIHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLICESRDK
FIRELFELSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHF
EGAQILSQLQCSGMVSVLDLMQGGFPSRASFHELYNMYKKYMPDKLARLD
PRLFCKALFKALGLNEIDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL
VKRVNHWL
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain4pk4 Chain A Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4pk4 How actin initiates the motor activity of Myosin.
Resolution2.78 Å
Binding residue
(original residue number in PDB)		S153 K157 S203 S204 G459
Binding residue
(residue number reindexed from 1)		S149 K153 S199 S200 G444
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) S153 G154 T158 N200 S203 S204 G459 E461
Catalytic site (residue number reindexed from 1) S149 G150 T154 N196 S199 S200 G444 E446
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4pk4, PDBe:4pk4, PDBj:4pk4
PDBsum4pk4
PubMed25936506
UniProtF1RQI7

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