Structure of PDB 4o7g Chain A Binding Site BS03

Receptor Information
>4o7g Chain A (length=211) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PIFMVVRVLGFIIAALVLTWTVHYRGGLALSSDNKDHIFNVHPVMMVIGL
ILFNGEAMLAYKSVQGTKNLKKLVHLTLQLTAFILSLIGVWAALKFHIDK
GIENFYSLHSWLGLACLFLFAFQWAAGFVTYWYPGGSRNSRASLMPWHVF
LGISIYALALVTATTGILEKVTFLQVNQVITRYSTEAMLVNTMGVLILIL
GGFVILGVVTP
Ligand information
Ligand IDASC
InChIInChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
InChIKeyCIWBSHSKHKDKBQ-JLAZNSOCSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC[CH](O)[CH]1OC(=O)C(=C1O)O
OpenEye OEToolkits 1.5.0C(C(C1C(=C(C(=O)O1)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O
CACTVS 3.341OC[C@H](O)[C@H]1OC(=O)C(=C1O)O
ACDLabs 10.04O=C1OC(C(O)=C1O)C(O)CO
FormulaC6 H8 O6
NameASCORBIC ACID;
Vitamin C
ChEMBLCHEMBL196
DrugBankDB00126
ZINCZINC000100006770
PDB chain4o7g Chain A Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4o7g Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase
Resolution2.211 Å
Binding residue
(original residue number in PDB)		F105 I111 F182
Binding residue
(residue number reindexed from 1)		F96 I102 F173
Annotation score5
Enzymatic activity
Enzyme Commision number 7.2.1.3: ascorbate ferrireductase (transmembrane).
Gene Ontology
Molecular Function
GO:0000293 ferric-chelate reductase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0140571 transmembrane ascorbate ferrireductase activity
Biological Process
GO:0019852 L-ascorbic acid metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4o7g, PDBe:4o7g, PDBj:4o7g
PDBsum4o7g
PubMed24449903
UniProtQ9SWS1|ACFR2_ARATH Transmembrane ascorbate ferrireductase 2 (Gene Name=CYB561B)

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