Structure of PDB 4o3m Chain A Binding Site BS03

Receptor Information
>4o3m Chain A (length=613) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILM
PTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYLTG
DKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLL
ARFVIDEAHRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKIL
RPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSR
RECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIA
FGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDV
TRLKRLIMMEKDHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFN
PDFCKKHPDVSCDNCCKYKTRDVTDDVKSIVRFVQEHSPSGRFTMNMLVD
IFLGSKSAKIQSGIFGKGSAYSRHNAERLFKKLILDKILDEDLYINANDQ
AIAYVMLGNKAQTVLNGNLKVDFMETENKVSQREEMVKKCLGELTEVCKS
LGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEV
ISVLQKYSEWTSP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4o3m Chain A Residue 1302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4o3m Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		C1036 C1055 C1066
Binding residue
(residue number reindexed from 1)		C385 C404 C415
Annotation score1
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0044237 cellular metabolic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:4o3m, PDBe:4o3m, PDBj:4o3m
PDBsum4o3m
PubMed24816114
UniProtP54132|BLM_HUMAN RecQ-like DNA helicase BLM (Gene Name=BLM)

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