Structure of PDB 4npk Chain A Binding Site BS03

Receptor Information
>4npk Chain A (length=269) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRV
IKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEV
EKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNVSNLDKVLTDIKADGLSS
ALLILYLDSARNLPSSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTF
FIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNS
GPNSTIKMKIALRVLHLEK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4npk Chain A Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4npk Structure and ca(2+)-binding properties of the tandem c2 domains of e-syt2.
Resolution2.552 Å
Binding residue
(original residue number in PDB)		D462 P463 D464 D466
Binding residue
(residue number reindexed from 1)		D83 P84 D85 D87
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006869 lipid transport
GO:0061817 endoplasmic reticulum-plasma membrane tethering

View graph for
Biological Process
External links
PDB RCSB:4npk, PDBe:4npk, PDBj:4npk
PDBsum4npk
PubMed24373768
UniProtA0FGR8|ESYT2_HUMAN Extended synaptotagmin-2 (Gene Name=ESYT2)

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