Structure of PDB 4n9v Chain A Binding Site BS03

Receptor Information

>4n9v Chain A (length=295) Species: 5059 (Aspergillus flavus)

SAVKAARYGKDNVRVYKVHKDEKTGVQTVYEMTVCVLLEGEIETSYTKAD
NSVIVATDSIKNTIYITAKQNPVTPPELFGSILGTHFIEKYNHIHAAHVN
IVCHRWTRMDIDGKPHPHSFIRDSEEKRNVQVDVVEGKGIDIKSSLSGLT
VLKSTNSQFWGFLRDEYTTLKETWDRILSTDVDATWQWKNFSGLQEVRSH
VPKFDATWATAREVTLKTFAEDNSASVQATMYKMAEQILARQQLIETVEY
SLPNKHYFEIDLSWHKGLQNTGKNAEVFAPQSDPNGLIKCTVGRS

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 4n9v Chain A Residue 406

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4n9v The neutron structure of urate oxidase resolves a long-standing mechanistic conundrum and reveals unexpected changes in protonation.
• Resolution: 1.1 Å
• Binding residue (original residue number in PDB): D11 C35
• Binding residue (residue number reindexed from 1): D11 C35
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): K10 T57 R176 Q228 H256
• Catalytic site (residue number reindexed from 1): K10 T57 R176 Q228 H256
• Enzyme Commision number: 1.7.3.3: factor independent urate hydroxylase.

Gene Ontology

Molecular Function

• GO:0004846 urate oxidase activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0006144 purine nucleobase metabolic process
• GO:0006145 purine nucleobase catabolic process
• GO:0019628 urate catabolic process

Cellular Component

• GO:0005777 peroxisome

External links

• PDB: RCSB:4n9v, PDBe:4n9v, PDBj:4n9v
• PDBsum: 4n9v
• PubMed: 24466188
• UniProt: Q00511|URIC_ASPFL Uricase (Gene Name=uaZ)