Structure of PDB 4mit Chain A Binding Site BS03

Receptor Information
>4mit Chain A (length=178) Species: 885315 (Entamoeba histolytica HM-3:IMSS) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTSIKLVVVGDGAVGKTCLLISYSIRKFPEDYIPTVFDNYVVSLTAGTRQ
IQLALWDTAGLEEYDQLRPLSYSSASIFLICFSVTSSVSYDNVITKWHPE
VIHFAPKVPIILVGTKLDTRNDPAIVKRLTEQGMTVINTAKGEELKNRIK
AVKYIECSAKTSENLKTVFDEAVKTVLM
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4mit Chain A Residue 204 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4mit Entamoeba histolytica RacC Selectively Engages p21-Activated Kinase Effectors.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		A112 P113 K114
Binding residue
(residue number reindexed from 1)		A105 P106 K107
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0007264 small GTPase-mediated signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4mit, PDBe:4mit, PDBj:4mit
PDBsum4mit
PubMed25529118
UniProtQ24816|RACC_ENTH1 Rho-related protein racC (Gene Name=RACC)

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