Structure of PDB 4lt5 Chain A Binding Site BS03

Receptor Information
>4lt5 Chain A (length=265) Species: 5762 (Naegleria gruberi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INKKSLLQNLLSKCKTTFQQSFTNANITLKDEKWLKNVRTAYFVCDHDGS
VELAYLPNVLPKELVEEFTEKFESIQTGRKKDTGYSGILDNSMPFNYVTA
DLSQELGQYLSEIVNPQINYYISKLLTCVSSRTINYLVSLNDSYYALNNC
LYPSTAFNSLKPSNDGHRIRKPHKDNLDITPSSLFYFGNFQNTEGYLELT
DKNCKVFVQPGDVLFFKGNEYKHVVANITSGWRIGLVYFAHKGSKTKPYY
EDTQKNSLKIHKETK
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4lt5 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4lt5 Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA.
Resolution2.893 Å
Binding residue
(original residue number in PDB)		H229 D231 H279
Binding residue
(residue number reindexed from 1)		H173 D175 H223
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005506 iron ion binding
GO:0010385 double-stranded methylated DNA binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0070579 5-methylcytosine dioxygenase activity

View graph for
Molecular Function
External links
PDB RCSB:4lt5, PDBe:4lt5, PDBj:4lt5
PDBsum4lt5
PubMed24390346
UniProtD2W6T1|TET1_NAEGR Tet-like dioxygenase 1 (Gene Name=TET1)

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