Structure of PDB 4lhd Chain A Binding Site BS03

Receptor Information
>4lhd Chain A (length=952) Species: 1111708 (Synechocystis sp. PCC 6803 substr. Kazusa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AIAVDLTKLEEKLAPADSFLDRHLGPGETEQRQMLQTLGFDTLGDLIDQA
VPPAIRFPRSLQLPASQSEYGAIAQLKSIASKNQVFRSYIGMGYYDTITP
PVIQRNILENPGWYTAYTPYQAEIAQGRLEALLNFQTMVMDLTGLEIANA
SLLDEGTAAAEAMALSYGVSKSKANAFFVAQDCHPQTIEVIKTRANPLGI
EVIVGDHHTFSFSTSIFGALLQYPATDGAVYDYRSFIDKAHQHQALVTLA
ADPLSLTLLTPPGELGADIAVGSTQRFGIPLGYGGPHAAYFATKAEYQRK
MPGRIVGVSKDAHGNPALRLALQTREQHIRRDKATSNICTAQVLLAVMAS
MYGVYHGSTGLKNIALRIHQLTVLLAIGLKRLNYSLNNDYFFDTLRVGVG
EQSAPAILKAAEGRGINLRPLVPGEVGISLDETVTVQDLLDLWQVFAGKD
NLPFTPEELWSEVKTSFPADLTRQSLYLQDAVFNQYHSETELLRYLHQLE
SKDLALNTSMIPLGSCTMKLNATAEMMPVTWPEFGKIHPFAPAGQTEGYQ
ILFAQLEAWLGEITGFDAISLQPNAGSQGEYAGLQVIRQYHLSRGEEQRN
ICLIPESAHGTNPASAVMCGMQVVPVKCDGEGNIDVEDLTSKAEKYGDRL
AALMVTYPSTHGVFEATIGTICDIVHRFGGEVYMDGANMNAQVGLCRPAD
FGADVCHLNLHKTFCIPHGGGGPGMGPIGVKSHLQAFLPRTDQSIGMISA
APYGSASILVISWMYIAMMGPQGLTKATEVAILSANYMAKRLENYYPILF
RGNNELVAHECILDLRPLKKQAAIEVEDVAKRLMDFGFHAPTVSWPVLGT
MMVEPTESESLGELDRFCDAMIAIYQEAQAITHGEIDPADNPLKNAPHTA
QSLICGEWNHPYSQEEAAYPAPWTKQFKFWPAVGRINNTYGDRHLVCSCE
GM
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain4lhd Chain A Residue 1004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4lhd Structure of the Homodimeric Glycine Decarboxylase P-protein from Synechocystis sp. PCC 6803 Suggests a Mechanism for Redox Regulation.
Resolution1.7959 Å
Binding residue
(original residue number in PDB)		N647 A680 N828
Binding residue
(residue number reindexed from 1)		N633 A666 N803
Annotation score5
Enzymatic activity
Enzyme Commision number 1.4.4.2: glycine dehydrogenase (aminomethyl-transferring).
Gene Ontology
Molecular Function
GO:0004375 glycine dehydrogenase (decarboxylating) activity
GO:0016491 oxidoreductase activity
GO:0016594 glycine binding
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006544 glycine metabolic process
GO:0006546 glycine catabolic process
GO:0019464 glycine decarboxylation via glycine cleavage system
Cellular Component
GO:0005829 cytosol
GO:0005960 glycine cleavage complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4lhd, PDBe:4lhd, PDBj:4lhd
PDBsum4lhd
PubMed24121504
UniProtP74416|GCSP_SYNY3 Glycine dehydrogenase (decarboxylating) (Gene Name=gcvP)

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