Structure of PDB 4l9s Chain A Binding Site BS03

Receptor Information
>4l9s Chain A (length=159) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSD
DVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFY
TLVREIRQH
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4l9s Chain A Residue 204 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4l9s K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
Resolution1.606 Å
Binding residue
(original residue number in PDB)		V103 D105
Binding residue
(residue number reindexed from 1)		V96 D98
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4l9s, PDBe:4l9s, PDBj:4l9s
PDBsum4l9s
PubMed24256730
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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