Structure of PDB 4ku8 Chain A Binding Site BS03

Receptor Information
>4ku8 Chain A (length=150) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQ
GARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVR
TANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAF
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain4ku8 Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ku8 Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I.
Resolution1.994 Å
Binding residue
(original residue number in PDB)		G217 S218 L221
Binding residue
(residue number reindexed from 1)		G1 S2 L5
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.12: cGMP-dependent protein kinase.
Gene Ontology
Molecular Function
GO:0004692 cGMP-dependent protein kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4ku8, PDBe:4ku8, PDBj:4ku8
PDBsum4ku8
PubMed24239458
UniProtQ13976|KGP1_HUMAN cGMP-dependent protein kinase 1 (Gene Name=PRKG1)

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