Structure of PDB 4kpy Chain A Binding Site BS03

Receptor Information
>4kpy Chain A (length=676) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNHLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVA
RRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDP
KDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGG
AVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRR
TWELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKPI
PHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAV
RAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPE
FLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVL
TPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAG
LQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQ
AGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALE
ALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRD
FRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLA
DRLVKEVGRLGIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4kpy Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Resolution2.406 Å
Binding residue
(original residue number in PDB)		P44 R51 R114 G547 R574 K575 S576
Binding residue
(residue number reindexed from 1)		P44 R51 R114 G538 R565 K566 S567
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:4kpy, PDBe:4kpy, PDBj:4kpy
PDBsum4kpy
PubMed24374628
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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