Structure of PDB 4jej Chain A Binding Site BS03

Receptor Information

>4jej Chain A (length=241) Species: 376686 (Flavobacterium johnsoniae UW101)

KILTTIHQQILEAKKNGQKLLAILLDPDKIVWENLDHLLLKINQSPATHI
FVGGSIVESTIIEDLIAQLKQKTRLPVVIFPGDPSQISPKADAILFLSLL
SGRNPDYLIEYQVQAAPILKKTNLEVISTGYILIESGNETAVARVSKTEP
LNRENFDLALATAQAGEMLGSKLIYLEAGSGAKKPVPLEMISVISQNVEI
PIIVGGGIVDLHGIKKAYNAGADLVVIGTAFENDSHFFDSL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4jej Chain A Residue 304

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4jej A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.
• Resolution: 1.52 Å
• Binding residue (original residue number in PDB): G209 I211
• Binding residue (residue number reindexed from 1): G206 I208
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.5.1.41: phosphoglycerol geranylgeranyltransferase.

Gene Ontology

Molecular Function

• GO:0000107 imidazoleglycerol-phosphate synthase activity
• GO:0000287 magnesium ion binding
• GO:0016740 transferase activity
• GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
• GO:0046872 metal ion binding
• GO:0047294 phosphoglycerol geranylgeranyltransferase activity

Biological Process

• GO:0006650 glycerophospholipid metabolic process
• GO:0008654 phospholipid biosynthetic process
• GO:0046474 glycerophospholipid biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4jej, PDBe:4jej, PDBj:4jej
• PDBsum: 4jej
• PubMed: 24684232
• UniProt: A5FJK8|GGGPS_FLAJ1 Geranylgeranylglyceryl phosphate synthase (Gene Name=Fjoh_1584)