Structure of PDB 4izm Chain A Binding Site BS03

Receptor Information
>4izm Chain A (length=404) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFVRLLKMLVMPIV
FASCVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMARLFNPGAG
IHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQVLPTIFFAIILG
IAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFAL
IAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFI
KHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYCFTLPLGATINMD
GTALYQGVATFFIANALGSHLTVGQQLTIVLTAVLASIGTAGVPGAGAIM
LAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIV
AKTE
Ligand information
Ligand IDASP
InChIInChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
InChIKeyCKLJMWTZIZZHCS-REOHCLBHSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(C(=O)O)N)C(=O)O
OpenEye OEToolkits 1.7.0C([C@@H](C(=O)O)N)C(=O)O
CACTVS 3.370N[CH](CC(O)=O)C(O)=O
CACTVS 3.370N[C@@H](CC(O)=O)C(O)=O
ACDLabs 12.01O=C(O)CC(N)C(=O)O
FormulaC4 H7 N O4
NameASPARTIC ACID
ChEMBLCHEMBL274323
DrugBankDB00128
ZINCZINC000000895032
PDB chain4izm Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4izm Binding thermodynamics of a glutamate transporter homolog.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		R276 S277 S278 G354 A358 G359 D394 R397 T398
Binding residue
(residue number reindexed from 1)		R264 S265 S266 G342 A346 G347 D382 R385 T386
Annotation score3
Binding affinityPDBbind-CN: -logKd/Ki=6.66,Kd=220nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005283 amino acid:sodium symporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015501 glutamate:sodium symporter activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006865 amino acid transport
GO:0035725 sodium ion transmembrane transport
GO:0046942 carboxylic acid transport
GO:0070207 protein homotrimerization
GO:0070778 L-aspartate transmembrane transport
GO:0140009 L-aspartate import across plasma membrane
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4izm, PDBe:4izm, PDBj:4izm
PDBsum4izm
PubMed23563139
UniProtO59010|GLT_PYRHO Glutamate transporter homolog (Gene Name=PH1295)

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