Structure of PDB 4iks Chain A Binding Site BS03
Receptor Information
>4iks Chain A (length=304) Species:
9606
(Homo sapiens) [
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YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKL
LSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHG
DLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHA
QANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMI
CEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARP
HFMS
Ligand information
Ligand ID
CO
InChI
InChI=1S/Co/q+2
InChIKey
XLJKHNWPARRRJB-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Co+2]
CACTVS 3.341
[Co++]
Formula
Co
Name
COBALT (II) ION
ChEMBL
DrugBank
DB14205
ZINC
PDB chain
4iks Chain A Residue 403 [
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Receptor-Ligand Complex Structure
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PDB
4iks
Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
Resolution
1.7 Å
Binding residue
(original residue number in PDB)
D229 D240 E367
Binding residue
(residue number reindexed from 1)
D140 D151 E278
Annotation score
3
Enzymatic activity
Catalytic site (original residue number in PDB)
D229 D240 H303 H310 E336 E367
Catalytic site (residue number reindexed from 1)
D140 D151 H214 H221 E247 E278
Enzyme Commision number
3.4.11.18
: methionyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0070006
metalloaminopeptidase activity
Biological Process
GO:0006508
proteolysis
View graph for
Molecular Function
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Biological Process
External links
PDB
RCSB:4iks
,
PDBe:4iks
,
PDBj:4iks
PDBsum
4iks
PubMed
23767698
UniProt
P53582
|MAP11_HUMAN Methionine aminopeptidase 1 (Gene Name=METAP1)
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