Structure of PDB 4hvl Chain A Binding Site BS03

Receptor Information

>4hvl Chain A (length=369) Species: 1078020 (Mycolicibacterium thermoresistibile ATCC 19527) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MIEPPVIDPAAVPPDETGPDNPMEQRRVCAAPTVYPDSNFADRPWASDYL
RLTEAHKFATGAGITVAVIDTGVNGSPRVPAEPGGDFVDAAGNGMSDCDA
HGTLTASVIAGRGAPTDGFIGVAPDARILSLRHTSAAFQPVGARTDPNNP
NTTQTAGSLRSLARAIVHAANLGAQVINISEAACYKVTRPIDETGVGAAV
NYAVHVKNAVVIAAAGNTGQDCTQNPPPDPAVPSDPRGWQQVQTIVSPAW
YSPLVLTVGGIGPTGQPSNFSMSGPWVGAAAPAENITALGYGGEPVNALQ
GQDGLVPVAGTSFAAAYVSGLAALIRQRYPDLTPAQVINRITATARHPGG
GVDNYVGAGVIDPVAALTW

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

4hvl Chain A Residue 506 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4hvl Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	H123 S334
Binding residue (residue number reindexed from 1)	H101 S312
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	D92 H123 N239 S334
Catalytic site (residue number reindexed from 1)	D70 H101 N217 S312
Enzyme Commision number	?

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:4hvl, PDBe:4hvl, PDBj:4hvl
PDBsum	4hvl
PubMed	24113528
UniProt	G7CDQ2

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