Structure of PDB 4hht Chain A Binding Site BS03

Receptor Information

>4hht Chain A (length=220) Species: 243274 (Thermotoga maritima MSB8)

GIDELYKKEFGIVAGVDEASRGCLAGPVVAAAVVLEKEIEGINDSRLLDE
IMEKAAVGIGIASPEEIDLYNIFNATKLAMNRALENLSVKPSFVLVDGKG
IELSVPGTCLVKGDQKSKLIGAASIVAKVFRDRLMSEFHRMYPQFSFHKH
KGYATKEHLNEIRKNGVLPIHRLSFEPVLELLTDDLLREFFEKGLISENR
FERILNLLGARKSVVFRKER

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 4hht Chain A Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4hht RNase H2 roles in genome integrity revealed by unlinking its activities.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): D18 E19
• Binding residue (residue number reindexed from 1): D17 E18
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.26.4: ribonuclease H.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0004523 RNA-DNA hybrid ribonuclease activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006298 mismatch repair
• GO:0006401 RNA catabolic process
• GO:0043137 DNA replication, removal of RNA primer

Cellular Component

• GO:0005737 cytoplasm
• GO:0032299 ribonuclease H2 complex

External links

• PDB: RCSB:4hht, PDBe:4hht, PDBj:4hht
• PDBsum: 4hht
• PubMed: 23355612
• UniProt: Q9X017|RNH2_THEMA Ribonuclease HII (Gene Name=rnhB)