Structure of PDB 4gz7 Chain A Binding Site BS03

Receptor Information
>4gz7 Chain A (length=492) Species: 99883 (Tetraodon nigroviridis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGEILIKGGKVVNEDCSFFSDVHIRGGKIVEVGPDLRVPPGARVIDATDR
LVIPGGIDTHTHMELAFMGTRAVDDFHIGTKAALAGGTTMILDFVMTQKG
QSLLEAYDLWRKTADPKVCCDYSLHVAVTWWSDEVKDEMRTLAQERGVNS
FKMFMAYKGLFMLRDDELYAVFSHCKEVGAIAQVHAENGDLIAEGAKKML
SLGITGPEGHELCRPEAVEAEATQRAITIASAVNCPLYVVHVMSKSAADV
VSKARKDGRVVFGEPIAASLGTDGTNYWHKDWAHAAQYVMGPPLRPDPST
PGYLMDLLANDDLTLTGTDNCTFSRCQKALGKDDFTRIPNGVNGVEDRMS
VIWEKGVHSGKMDENRFVAVTSSNAAKIFNFYPQKGRIAKDSDADVVIWD
PKTTRKISAQTHHQAVDYNIFEGMECHGVPVVTVSRGRVVYEEGRLKVSP
GQGRFIHRQPFSEFVYKRIRQRDEVGKPAVVIREPYAGEVVA
Ligand information
Ligand IDMHA
InChIInChI=1S/C6H10N2O5/c7-4(9)1-8(2-5(10)11)3-6(12)13/h1-3H2,(H2,7,9)(H,10,11)(H,12,13)
InChIKeyQZTKDVCDBIDYMD-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341NC(=O)CN(CC(O)=O)CC(O)=O
OpenEye OEToolkits 1.5.0C(C(=O)N)N(CC(=O)O)CC(=O)O
ACDLabs 10.04O=C(O)CN(CC(=O)N)CC(=O)O
FormulaC6 H10 N2 O5
Name(CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID;
N-(2-ACETAMIDO)IMINODIACETIC ACID
ChEMBL
DrugBankDB02810
ZINCZINC000002545127
PDB chain4gz7 Chain A Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4gz7 Lysine Carboxylation: Metal and Structure Requirements for Post-translational Modification
Resolution2.0 Å
Binding residue
(original residue number in PDB)		A199 H213 C216 R217 F338 T339 N343
Binding residue
(residue number reindexed from 1)		A196 H210 C213 R214 F335 T336 N340
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004157 dihydropyrimidinase activity
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0046872 metal ion binding
Biological Process
GO:0006208 pyrimidine nucleobase catabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4gz7, PDBe:4gz7, PDBj:4gz7
PDBsum4gz7
PubMed
UniProtH3C542

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