Structure of PDB 4g0u Chain A Binding Site BS03

Receptor Information
>4g0u Chain A (length=655) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRG
KILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMI
MTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITERHRILFRYAGPE
DDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLKHLTYNDFINKELILFS
NSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAY
HHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIF
TMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIG
TGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQY
AVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDY
KEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMG
CLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILE
KIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEGPDFNYILNMSL
WSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVES
QERED
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4g0u On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Resolution2.7 Å
Binding residue
(original residue number in PDB)		L507 N508 H564 F669 I674 R677 K678 R820 Y821 I872 G873 G875 T1010 T1012 N1014 S1015
Binding residue
(residue number reindexed from 1)		L53 N54 H110 F159 I164 R167 K168 R297 Y298 I349 G350 G352 T487 T489 N491 S492
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4g0u, PDBe:4g0u, PDBj:4g0u
PDBsum4g0u
PubMed24038465
UniProtQ02880|TOP2B_HUMAN DNA topoisomerase 2-beta (Gene Name=TOP2B)

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