Structure of PDB 4fyd Chain A Binding Site BS03

Receptor Information
>4fyd Chain A (length=848) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDTFQMFWLDYCEVNNTLILFGKVKLKDDNCVSAMVQINGLCRELFFLPR
EGKTPTDIHEEIIPLLMDKYGLDNIRAKPQKMKYSFELPDIPSESDYLKV
LLPYQTPKSSRDTIPSDLSSDTFYHVFGGNSNIFESFVIQNRIMGPCWLD
IKGADFNSSHCAVEVSVDKPQNITPTTTKTMPNLRCLSLSIQTLMNPKEN
KQEIVSITLSAYRNISLDSPIPENIKPDDLCTLVRPPQSTSFPLGLAALA
KQKLPGRVRLFNNEKAMLSCFCAMLKVEDPDVIIGHRLQNVYLDVLAHRM
HDLNIPTFSSIGRRLRRTWPEKFGNMNHFFISDICSGRLICDIANEMGQS
LTPKCQSWDLSEMYQVTCEKEHKPLDIDYQNPQYQNDVNSMTMALQENIT
NCMISAEVSYRIQLLTLTKQLTNLAGNAWAQTLGGTRAGRNEYILLHEFS
RNGFIVPDKAKYQGGLVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFT
TVDRNKEDIDELPSVPPSEVDQGVLPRLLANLVDRRREVKKVMKTETDPH
KRVQCDIRQQALKLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNT
RQLAESMNLLVVYGDTNSVMIDTGCDNYADAIKIGLGFKRLVNERYRLLE
IDIDNVFKKLLLHAKKKYAALTVNLDKNGNGTTVLEVKGLDMKRREFCPL
SRDVSIHVLNTILSDKDPEEALQEVYDYLEDIRIKVETNNIRIDKYKINM
KLSKDPKAYPGGKNMPAVQVALRMRKAGRVVKAGSVITFVITKSVAERAH
ALNEVMIKSNNLIPDPQYYLEKQIFAPVERLLERIDSFNVVRLSEALG
Ligand information
Receptor-Ligand Complex Structure
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PDB4fyd Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Y843 Q844 D891 L893 M968
Binding residue
(residue number reindexed from 1)		Y462 Q463 D510 L512 M587
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:1902975 mitotic DNA replication initiation

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Molecular Function
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Biological Process
External links
PDB RCSB:4fyd, PDBe:4fyd, PDBj:4fyd
PDBsum4fyd
PubMed23599895
UniProtP13382|DPOLA_YEAST DNA polymerase alpha catalytic subunit A (Gene Name=POL1)

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