Structure of PDB 4fo8 Chain A Binding Site BS03

Receptor Information

>4fo8 Chain A (length=259) Species: 208964 (Pseudomonas aeruginosa PAO1)

TVTIKTPDDIEKMRIAGRLAAEVLEMIGEHIKPGVTTEELDRICHDYIVN
EQKAIPAPLNYKGFPKSICTSINHVVCHGIPNEKPLKEGDILNVDITVIK
DGYHGDTSKMFLVGKTPEWADRLCQITQECMYKGISVVRPGAHLGDIGEI
IQKHAEKNGFSVVREYCGHGIGKVFHEEPQVLHYGRAGTGIELKEGMIFT
IEPMINQGRPETRLLGDGWTAITKDRKLSAQWEHTVLVTADGYEILTLRN
DETFPRTSA

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 4fo8 Chain A Residue 304

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4fo8 Methionine excision captured by the structures of a methionine aminopeptidase
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): N74 V76 S230
• Binding residue (residue number reindexed from 1): N73 V75 S229
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): D96 D107 H170 H177 E203 E234
• Catalytic site (residue number reindexed from 1): D95 D106 H169 H176 E202 E233
• Enzyme Commision number: 3.4.11.18: methionyl aminopeptidase.

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0004239 initiator methionyl aminopeptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0046872 metal ion binding
• GO:0046914 transition metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:4fo8, PDBe:4fo8, PDBj:4fo8
• PDBsum: 4fo8
• UniProt: Q9HXY1