Structure of PDB 4fm0 Chain A Binding Site BS03

Receptor Information
>4fm0 Chain A (length=754) Species: 272844 (Pyrococcus abyssi GE5) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGMIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSAI
DEVKKITAERHGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIRE
KIREHPAVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYHE
GEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKVI
REKDPDVIITYNGDNFAFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDSL
AVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAEA
WETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRSS
TGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYKEPEKGLWEGIVS
LDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGFIPSL
LGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYGYAKA
RWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIPGAKH
EEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDEEGKI
VTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEKLSKY
EIPPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVIGYIV
LRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAVERILRAFGYRKE
DLKY
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4fm0 Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4fm0 Molecular Recognition of Canonical and Deaminated Bases by P. abyssi Family B DNA Polymerase.
Resolution3.12 Å
Binding residue
(original residue number in PDB)		D141 E143 D315
Binding residue
(residue number reindexed from 1)		D143 E145 D317
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0071897 DNA biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4fm0, PDBe:4fm0, PDBj:4fm0
PDBsum4fm0
PubMed22902479
UniProtP0CL77|DPOL_PYRAB DNA polymerase 1 (Gene Name=polI)

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