Structure of PDB 4flu Chain A Binding Site BS03

Receptor Information
>4flu Chain A (length=758) Species: 29292 (Pyrococcus abyssi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HAGMIIDADYITEDGKPIIRIFKKEKGEFKVEYDRTFRPYIYALLKDDSA
IDEVKKITAERHGKIVRITEVEKVQKKFLGRPIEVWKLYLEHPQDVPAIR
EKIREHPAVVDIFEYDIPFAKRYLIDKGLTPMEGNEELTFLAVDIETLYH
EGEEFGKGPIIMISYADEEGAKVITWKSIDLPYVEVVSSEREMIKRLVKV
IREKDPDVIITYNGDNFAFPYLLKRAEKLGIKLPLGRDNSEPKMQRMGDS
LAVEIKGRIHFDLFPVIRRTINLPTYTLEAVYEAIFGKSKEKVYAHEIAE
AWETGKGLERVAKYSMEDAKVTFELGKEFFPMEAQLARLVGQPVWDVSRS
STGNLVEWFLLRKAYERNELAPNKPDEREYERRLRESYEGVKEPEKGLWE
GIVSLDFRSLYPSIIITHNVSPDTLNRENCKEYDVAPQVGHRFCKDFPGF
IPSLLGNLLEERQKIKKRMKESKDPVEKKLLDYRQRAIKILANSYYGYYG
YAKARWYCKECAESVTAWGRQYIDLVRRELESRGFKVLYIDTDGLYATIP
GAKHEEIKEKALKFVEYINSKLPGLLELEYEGFYARGFFVTKKKYALIDE
EGKIVTRGLEIVRRDWSEIAKETQAKVLEAILKHGNVDEAVKIVKEVTEK
LSKYEIPPEKLVIYEQITRPLSEYKAIGPHVAVAKRLAAKGVKVKPGMVI
GYIVLRGDGPISKRAIAIEEFDPKKHKYDAEYYIENQVLPAVERILRAFG
YRKEDLKY
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4flu Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4flu Molecular Recognition of Canonical and Deaminated Bases by P. abyssi Family B DNA Polymerase.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D141 E143 D315
Binding residue
(residue number reindexed from 1)		D144 E146 D318
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0071897 DNA biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4flu, PDBe:4flu, PDBj:4flu
PDBsum4flu
PubMed22902479
UniProtP0CL76|DPOL_PYRAY DNA polymerase 1 (Gene Name=polI)

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