Structure of PDB 4fkc Chain A Binding Site BS03

Receptor Information
>4fkc Chain A (length=370) Species: 604354 (Thermococcus sibiricus MM 739) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHGSMDYKRRIHKFQAHFGKKGFEGALVAPGSNFYYLTGFNPLGTLERL
FVLILPSEGLLTAIAPRLYEKELEEFNGEVVLWSDSENPYKIFATKIKET
FKEGEKLLIDDTMPVGVFLKAKDIFDKYSLHPISPVISELREIKDKDEIK
AHKKAAEIVDKVFYRFIEGKLEGKSERELANRIEYMIKNEFGADDVSFEP
IVASGPNGANPHHRPSHRKIRKGDVVIFDYGAKYLGYCSDVTRTVVVGPP
SEEVKKVYEIVKEAQETAVQKVAEGIPAEVVDATARGIISKYGYGEYFIH
RTGHGLGIDVHEEPYISPGNKKILKDGMVFTIEPGIYLQGKFGVRIEDDV
ALVDKKGIRLTNADRELITL
Ligand information
Ligand IDCD
InChIInChI=1S/Cd/q+2
InChIKeyWLZRMCYVCSSEQC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Cd++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cd+2]
FormulaCd
NameCADMIUM ION
ChEMBL
DrugBank
ZINC
PDB chain4fkc Chain A Residue 408 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4fkc Influence of intermolecular contacts on the structure of recombinant prolidase from Thermococcus sibiricus.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		H2 D147
Binding residue
(residue number reindexed from 1)		H2 D147
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) H212 D229 D240 H300 H304 H311 E333 Y337 R345 E347
Catalytic site (residue number reindexed from 1) H212 D229 D240 H300 H304 H311 E333 Y337 R345 E347
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4fkc, PDBe:4fkc, PDBj:4fkc
PDBsum4fkc
PubMed23143231
UniProtC6A2N7

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