Structure of PDB 4ezd Chain A Binding Site BS03

Receptor Information
>4ezd Chain A (length=345) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GYITGDMKEFANWLKDKPQALQFVDWVLRGISQVVFVSNPISGILILVGL
LVQNPWCALNGCVGTVVSTLTALLLSQDRSAITAGLQGYNATLVGILMAI
YSDKGNYFWWLLFPVSAMSMTCPVFSSALNSVLSKWDLPVFTLPFNMALS
MYLSATGHYNPFFPSTLITPVTSVPNVTWPDLSALQLLKSLPVGVGQIYG
CDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIIAGLSLSAPFEDIYAGL
WGFNSSLACIAIGGTFMALTWQTHLLALACALFTAYLGASMSHVMAVVGL
PSGTWPFCLATLLFLLLTTKNPNIYKMPISKVTYPEENRIFYLQS
Ligand information
Ligand IDBGC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-VFUOTHLCSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O
CACTVS 3.370OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.7.6C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
ACDLabs 12.01OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namebeta-D-glucopyranose;
beta-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL1614854
DrugBankDB02379
ZINCZINC000003833800
PDB chain4ezd Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ezd Structure and permeation mechanism of a mammalian urea transporter.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Y137 W139
Binding residue
(residue number reindexed from 1)		Y107 W109
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015204 urea transmembrane transporter activity
GO:0015265 urea channel activity
Biological Process
GO:0071918 urea transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ezd, PDBe:4ezd, PDBj:4ezd
PDBsum4ezd
PubMed22733730
UniProtQ5QF96|UT1_BOVIN Urea transporter 1 (Gene Name=SLC14A1)

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