Structure of PDB 4dbq Chain A Binding Site BS03

Receptor Information
>4dbq Chain A (length=744) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKPVWAPHPTDGFQVGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEE
DSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDI
PKIYSSETIKSYQGKSLGTMPPHVFAIADKAFRDMKVLKLSQSIIVSGES
GAGKTENTKFVLRYLTESYGTGQDIYDRIVEANPLLEAFGNAKTVRNNNS
SRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCA
GASEDIRERLHLSSPDNFRYLNRDPLLDDHGDFIRMCTAMKKIGLDDEEK
LDLFRVVAGVLHLGNIDFCNLKNKSTQALEYCAELLGLDQDDLRVSLTTR
VMVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLD
IAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEV
HYVDNQDCIDLIEARLVGILDILDEENRLPQPSDQHFTSAVHQKHKDHFR
LSIPRKSKLAIHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLE
SLICESRDKFIRELFESLSFISVGNKFKTQLNLLLDKLRSTGASFIRCIK
PNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRASFHELYNMYKK
YMPDKLARLDPRLFCKALFKALGLNEIDYKFGLTKVFFRPGKFAEFDQIM
KSDPDHLAELVKRVNHWLICSRWKKVQWCSLSVIKLKNKIKYRA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4dbq Chain A Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4dbq Mutations in myosin VI that cause a loss of coordination between heads provide insights into the structural changes underlying force generation and the importance of gating
Resolution2.6 Å
Binding residue
(original residue number in PDB)		T158 S204
Binding residue
(residue number reindexed from 1)		T155 S201
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) S153 G154 T158 N200 S203 S204 G459 E461
Catalytic site (residue number reindexed from 1) S150 G151 T155 N197 S200 S201 G403 E405
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4dbq, PDBe:4dbq, PDBj:4dbq
PDBsum4dbq
PubMed
UniProtQ29122|MYO6_PIG Unconventional myosin-VI (Gene Name=MYO6)

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