Structure of PDB 4d4z Chain A Binding Site BS03

Receptor Information
>4d4z Chain A (length=288) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPLGSMVTEQEVDAIGQTLVDPKQPLQARFRALFTLRGLGGPGAIAWISQ
AFDDDSALLKHELAYCLGQMQDARAIPMLVDVLQDTRQEPMVRHEAGEAL
GAIGDPEVLEILKQYSSDPVIEVAETCQLAVRRLEWLQQHGGEPAAGPYL
SVDPAPPAEERDVGRLREALLDESRPLFERYRAMFALRNAGGEEAALALA
EGLHCGSALFRHEVGYVLGQLQHEAAVPQLAAALARCTENPMVRHECAEA
LGAIARPACLAALQAHADDPERVVRESCEVALDMYEHE
Ligand information
Ligand IDGOL
InChIInChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
InChIKeyPEDCQBHIVMGVHV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(CO)O)O
ACDLabs 12.01
CACTVS 3.370		OCC(O)CO
FormulaC3 H8 O3
NameGLYCEROL;
GLYCERIN;
PROPANE-1,2,3-TRIOL
ChEMBLCHEMBL692
DrugBankDB09462
ZINCZINC000000895048
PDB chain4d4z Chain A Residue 305 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4d4z Crystal Structure of the Peroxo-Diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		H89 E90 E93 H207 E208 Y211 E241
Binding residue
(residue number reindexed from 1)		H94 E95 E98 H212 E213 Y216 E246
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.99.29: deoxyhypusine monooxygenase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0019135 deoxyhypusine monooxygenase activity
GO:0046872 metal ion binding
Biological Process
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4d4z, PDBe:4d4z, PDBj:4d4z
PDBsum4d4z
PubMed25865244
UniProtQ9BU89|DOHH_HUMAN Deoxyhypusine hydroxylase (Gene Name=DOHH)

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