Structure of PDB 4d0e Chain A Binding Site BS03

Receptor Information
>4d0e Chain A (length=122) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPC
QNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINE
FQCECPTGFTGHLCQVDLHHIL
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4d0e Chain A Residue 1532 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4d0e Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Resolution1.61 Å
Binding residue
(original residue number in PDB)		N490 T491 E493 D507 K508
Binding residue
(residue number reindexed from 1)		N79 T80 E82 D96 K97
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:4d0e, PDBe:4d0e, PDBj:4d0e
PDBsum4d0e
PubMed24803430
UniProtP46531|NOTC1_HUMAN Neurogenic locus notch homolog protein 1 (Gene Name=NOTCH1)

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