Structure of PDB 4clw Chain A Binding Site BS03

Receptor Information

>4clw Chain A (length=458) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MNTPKEEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISG
FTAMTEKFSSAMYMDRGAEQLVEILNYHISAIVEKVLIFGGDILKFAGDA
LLALWRVERKQLKNIITVVIKCSLEIHGLFLDIRVKIGLAAGHISMLVFG
DETHSHFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIESVP
DQRAVKVNFLKPPPNFNFDEFFTKCTTFMHYYPSGEHKNLLRLACTLKPD
PELEMSLQKYVMESILKQIDNKQLQGYLSELRPVTIVFVNLMFEDQDKAE
EIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDE
LTHALECAMDIFDFCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIG
QKVNLAARMMMYYPGIVTCDSVTYNGSNLPAYFFKELPKKVMKGVADSGP
LYQYWGRT

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

4clw Chain A Residue 1474 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4clw Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate.
Resolution	2.15 Å
Binding residue (original residue number in PDB)	D47 I48 D99
Binding residue (residue number reindexed from 1)	D47 I48 D99
Annotation score	1

Enzymatic activity

Enzyme Commision number

4.6.1.1: adenylate cyclase.

Gene Ontology

	Biological Process
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction

View graph for
Biological Process

External links

PDB	RCSB:4clw, PDBe:4clw, PDBj:4clw
PDBsum	4clw
PubMed	24567411
UniProt	Q96PN6\|ADCYA_HUMAN Adenylate cyclase type 10 (Gene Name=ADCY10)

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