Structure of PDB 4boc Chain A Binding Site BS03

Receptor Information
>4boc Chain A (length=989) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLSGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAV
MLGWARQGAFKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIE
RCLEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPP
VNTSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSV
EKPTLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSL
YPFLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQ
RVSGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEELGAPEALREQPW
PLPVQMELGKLLAEMLVQATQMPCSLDRSSRLVPVLYHVYSFRNVQQIGI
LKPHPAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTKL
MRTVEGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQL
FQAKGCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVAR
EMHSLRAEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSDV
ARALLEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEEVMDD
ILDSADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSHLPVH
QDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQD
AQRGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSDF
PQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVEW
VTPLGVPVIQPYRLDSRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCYR
KGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKRF
CSEPQKILEASQLKETLQAVPKPGAFDLEQVKRSTYFFS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4boc Structure of Human Mitochondrial RNA Polymerase Elongation Complex
Resolution2.65 Å
Binding residue
(original residue number in PDB)		Q493 S611 R672 R759 R770 H773 S774 A777 E778 Y781 R803 Y807 P811 T996 G1000 V1001 T1002 Y1004 G1005 R1113 K1114
Binding residue
(residue number reindexed from 1)		Q276 S391 R452 R539 R550 H553 S554 A557 E558 Y561 R583 Y587 P591 T776 G780 V781 T782 Y784 G785 R872 K873
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4boc, PDBe:4boc, PDBj:4boc
PDBsum4boc
PubMed24096365
UniProtO00411|RPOM_HUMAN DNA-directed RNA polymerase, mitochondrial (Gene Name=POLRMT)

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