Structure of PDB 3zvn Chain A Binding Site BS03

Receptor Information
>3zvn Chain A (length=377) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WESLKKLLVFTASGVKPQGKVAAFNLDGTLITTRSGKVFPTSPSDWRILY
PEIPKKLQELAAEGYKLVIFTNQMGIGRGKLPAEVFKGKVEAVLEKLGVP
FQVLVATHAGLNRKPVSGMWDHLQEQANEGIPISVEDSVFVGDAAGRLAN
WAPGRKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDPRTI
SSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVHVNR
DTLGSWQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGVPCR
CFNFCATIEQARHNNRFREMTDPSHAPVSDMVMFSYRKQFEPPTLAEGFL
EILEIPFRLQEHLDPALQRLYRQFSEG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3zvn The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		G399 S400 Q402 R403
Binding residue
(residue number reindexed from 1)		G254 S255 Q257 R258
Enzymatic activity
Enzyme Commision number 2.7.1.78: polynucleotide 5'-hydroxyl-kinase.
3.1.3.32: polynucleotide 3'-phosphatase.
Gene Ontology
Molecular Function
GO:0046403 polynucleotide 3'-phosphatase activity
GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3zvn, PDBe:3zvn, PDBj:3zvn
PDBsum3zvn
PubMed22055185
UniProtQ9JLV6|PNKP_MOUSE Bifunctional polynucleotide phosphatase/kinase (Gene Name=Pnkp)

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